KRAS inhibitor Cmpd2( —— )

Catalog No. M16986 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

KRAS inhibitor Cmpd2
Note

Research use only, not for human use.
Brief Description

KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.
Description

KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro; inhibits cell proliferation in SW1990 cells with EC50 of 2.7 uM; the potency of Cmpd2 was strongly enhanced when prenylated K-RAS4B is associated with a lipid bilayer.
In Vitro

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In Vivo

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Synonyms

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Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

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Indication

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CAS Number

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Formula Weight

446.773
Molecular Formula

C21H21BrClN3O
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

5-bromo-N-((2R,4S)-2-(4-chlorobenzyl)piperidin-4-yl)-1H-indole-3-carboxamide

1. Fang Z, et al. Cell Chem Biol. 2018 Aug 14. pii: S2451-9456(18)30261-7. 2. Jansen JM, et al. PLoS One. 2017 Apr 6;12(4):e0174706.

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